Toy figures from the first game are also forward compatible with Giants, although there are also new versions, called 'Series 2', which have more powerful attributes than the originals. The game involves connecting a physical toy to the video game console through a 'Portal of Power' whichever toy is used creates a respective character in the game. The game introduced over 40 new toy figures, some of which are more than twice the size of the original Skylanders cast in both physical and virtual form. Skylanders: Giants builds upon the fundamentals of the first game, which merges a line of physical toy figures with a video game world.

This is the final Skylanders game to be owned by Vivendi before Activision became an independent company on 25 July 2013. It has also been released on the Wii U as a launch title in North America, Europe and Australia. It was released for Nintendo 3DS, PlayStation 3, Wii, and Xbox 360 on 17 October 2012 in Australia, on 19 October 2012 in Europe, on 21 October 2012 in North America, and on 22 November 2012 in Brazil by Neoplay.

16 new skylanders were introduced, including 8 'Giants': Bouncer, Crusher, Eye-Brawl, Hot Head, Ninjini, Swarm, Thumpback and Tree Rex. As the title suggests, it features larger Skylanders known as 'Giants', along with other new gameplay mechanics. Skylanders: Giants is a 2012 video game in the Skylanders series, a direct sequel to the 2011 game Skylanders: Spyro's Adventure and features the voices of Kevin Michael Richardson, Greg Ellis, Peter Lurie, Steve Blum, Dave Wittenberg, Carlos Alazraqui, Kevin Sorbo, Bobcat Goldthwait, Patrick Seitz and Julie Nathanson.

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